Optimization and evaluation of bilayer tablet of clonidine

The goal in designing sustained or controlled delivery systems is to reduce the frequency of dosing increase effectiveness drug by localization at action, reducing dose required providing uniform delivery. primary objective release ensure safety and improve efficacy drugs as well patient compliance. Bi-layer tablet suitable for sequential two combination, separate incompatible substances also which one layer immediate initial second maintenance dose. major work following: Clonidine frequently administered up 3 times a day. So, tablet, long term effect can be achieved this dosage form, help full high blood pressure attention deficit hyperactivity disorder (ADHD), with reduced fluctuation plasma concentration, Reduction side related toxicity